Xenical Research Today is a free monthly online journal that collates and summarizes the latest research about Xenical, including details on orlistat, side-effects, obesity, weight loss, dieting.

Beta-lactam congeners of orlistat as inhibitors of fatty acid synthase.

Zhang W, Richardson RD, Chamni S, Smith JW, Romo D

Department of Chemistry, Texas A&M University, College Station, TX 77842-3012, USA.

Beta-lactam derivatives of orlistat were prepared and their inhibitory activities toward the thioesterase domain of fatty acid synthase (FAS-TE) were evaluated using a recombinant form of the enzyme. While in general these derivatives showed lower potency compared to beta-lactones, a reasonably potent, lead compound (-)-9 (IC(50)=8.6microM) was discovered that suggests that this class of compounds should be evaluated further.

Published 3 April 2008 in Bioorg Med Chem Lett, 18(7): 2491-4.
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