Xenical Research Today is a free monthly online journal that collates and summarizes the latest research about Xenical, including details on orlistat, side-effects, obesity, weight loss, dieting.

Myopathy associated with chronic orlistat consumption: A case report.

Ringman JM, Mozaffar T

Alzheimer Disease Research Center, UCLA Department of Neurology, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA 90095-7226, USA.

The pathogenesis of myopathy due to HMG-CoA reductase inhibitors is not entirely clear but the existence of myopathy due to other lipid-lowering medications suggests it is mediated through effects on lipid metabolism. We describe a patient who developed a myopathy after 27 months of ingestion of orlistat that slowly improved after discontinuation of the drug. Orlistat may have caused this myopathy through depletion of a critical nutrient or through some as of yet undefined mechanism.

Published 23 April 2008 in Neuromuscul Disord.
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